Metagenomic Insights into the Anti-Obesity Effect of a Polysaccharide from Saccharina japonica

Metagenomic Insights into the Anti-Obesity Effect of a Polysaccharide from Saccharina japonica

Blog Article

Saccharina japonica polysaccharides exhibit great potential to be developed as anti-obesity and prebiotic health products, but the underlying mechanism has not been adequately addressed.In this study, we investigated the potential mechanism of a S.japonica polysaccharide fraction (SjC) in preventing high-fat-diet (HFD)-induced obesity in mice using 16S rRNA gene and shotgun metagenomic sequencing analysis.SjC was characterized as a 756 kDa sulfated polysaccharide and 16 weeks of SjC supplementation significantly alleviated HFD-induced obesity, insulin resistance, and glucose metabolism disorders.The 16S rRNA and metagenomic sequencing analysis a&d ej-123 demonstrated that SjC supplementation prevented gut microbiota dysbiosis mainly by regulating the relative abundance of Desulfovibrio and Akkermansia.

Metagenomic functional profiling demonstrated that SjC treatment mpu63zm/a predominantly suppressed the amino acid metabolism of gut microbiota.Linking of 16S rRNA genes with metagenome-assembled genomes indicated that SjC enriched at least 22 gut bacterial species with fucoidan-degrading potential including Desulfovibrio and Akkermansia, which showed significant correlations with bodyweight.In conclusion, our results suggest that SjC exhibits a promising potential as an anti-obesity health product and the interaction between SjC and fucoidan-degrading bacteria may be associated with its anti-obesity effect.